J Gynecol Oncol.  2018 Mar;29(2):e24. 10.3802/jgo.2018.29.e24.

Trends in single women with malignancy of the uterine cervix in United States

Affiliations
  • 1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA. koji.matsuo@med.usc.edu
  • 2Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
  • 3Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA.
  • 4Department of Obstetrics and Gynecology, Tokai University School of Medicine, Isehara, Japan.

Abstract


OBJECTIVE
To examine trends and characteristics of single women with malignancy of the uterine cervix.
METHODS
This is a retrospective observational study examining the United States population-based tumor registry (the Surveillance, Epidemiology, and End Results program). Time-specific trends in single marital status were examined in 3,294,208 women among 12 common female malignancies including 87,151 women with uterine cervical malignancy between 1973 and 2013.
RESULTS
While the proportion of single women in the majority of malignancies increased during the study time, the proportion of single women with cervical malignancy significantly increased more than in other malignancies (29.3% in 2013 from 6.3% in 1973). There was a surge in the proportion of single women with cervical malignancy starting in the early 1990s, exhibiting the largest annual percentage rate change (APC) among all examined malignancies (1.8%; 95% confidence interval [CI]=1.6, 2.0; p < 0.001). There was a significant decrease in the proportion of women aged < 40 years with cervical malignancy between 1989 and 2013 (APC, −1.2%; 95% CI=−1.4, −1.0; p < 0.001). However, when stratified by age, the proportion of single women aged ≥40 years increased significantly during the time (APC, 2.7%; 95% CI=2.3, 3.2; p < 0.001) but did not in those who were < 40 years (APC, 0.1%; 95% CI=−0.7, 0.6; p=0.850).
CONCLUSION
The proportion of single women with malignancy of the uterine cervix has significantly increased in the past 4 decades. This increase was most dramatic in single women aged ≥40 years. Improving screening strategies in single women aged ≥40 years may help reduce the incidence of this malignancy.

Keyword

Marital Status; Single Person; Uterine Cervical Neoplasms; Trends; Age Factors

MeSH Terms

Age Factors
Cervix Uteri*
Epidemiology
Female
Humans
Incidence
Marital Status
Mass Screening
Observational Study
Retrospective Studies
Single Person
United States*
Uterine Cervical Neoplasms
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