Nucl Med Mol Imaging.  2017 Dec;51(4):371-373. 10.1007/s13139-016-0426-9.

Radiation-Induced Giant Cell Granuloma Mimicking Relapsed Hodgkin Lymphoma at FDG-PET/CT

• Adams HJ
• de Klerk J
• Regelink J
• Heggelman
• Dubois SV
• Kwee TC

• KMID: 2403516
• DOI: http://doi.org/10.1007/s13139-016-0426-9

Abstract

A 22-year-old woman was diagnosed with intermediate risk stage II Hodgkin lymphoma and treated with three cycles of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by involved-field radiation therapy. A complete metabolic remission was achieved after two cycles of ABVD, which was maintained until three years after completion of treatment. Follow-up FDG-PET/CT four years after completion of treatment, however, showed a new FDG-avid (Deauville score of 4) lesion in the right scapula, suggesting relapsed disease. Computer tomography (CT)-guided biopsy of this lesion was performed and subsequent histological examination revealed a radiation-induced giant cell granuloma.

Keyword

Biopsy; FDG-PET/CT ; Giant cell granuloma; Hodgkin lymphoma

MeSH Terms

Biopsy
Bleomycin
Dacarbazine
Doxorubicin
Female
Follow-Up Studies
Giant Cells*
Granuloma, Giant Cell*
Hodgkin Disease*
Humans
Scapula
Vinblastine
Young Adult
Bleomycin
Dacarbazine
Doxorubicin
Vinblastine