Korean J Gastroenterol.  2018 Jan;71(1):18-23. 10.4166/kjg.2018.71.1.18.

The Prevalence of Nontuberculous Mycobacterial Lung Disease with orwithout Reflux Esophagitis

• Kang JB
• Lee DH
• Kwon SH
• Kim N
• Park YS
• Yoon H
• Shin CM
• Choi YJ

• KMID: 2402801
• DOI: http://doi.org/10.4166/kjg.2018.71.1.18

Abstract

BACKGROUND/AIMS
Gastrointestinal reflux disease (GERD) is defined as "˜a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications'. It is associated with various lung diseases, including bronchial asthma, chronic bronchitis, and bronchiectasis. GERD may also affect nontuberculous mycobacterial (NTM) lung disease. We presumed that the normal mucosal barrier of the bronchial epithelium is broken due to the aspiration of gastric juice and consequent chronic bronchial inflammation. This study investigated the prevalence of GERD in accordance with the presence or absence of NTM lung disease and analyzed the difference.
METHODS
We screened patients with NTM lung disease in this hospital between January 2011 and December 2015. Among these patients, gastroscopic examinations as a health check-up were performed on 93 patients. We obtained the prevalence of Reflux esophagitis (RE) in patients with NTM and compared it with the prevalence of RE in the normal control subjects.
RESULTS
Among 93 patients with NTM, patients without RE was 66.7% (62/93). RE-minimal change was diagnosed in 29.0% (27/93), and RE LA-A was diagnosed in 4.3% (4/93). Comparing the prevalence of RE minimal change, 29.0% (27/93) had NTM and 11.9% (3043/25536) did not have NTM. This was statistically significant.
CONCLUSIONS
We showed a greater prevalence of RE minimal change in patients with NTM than those without NTM with statistical significance.

Keyword

Nontuberculous mycobacteria; Reflux esophagitis; GERD

MeSH Terms

Asthma
Bronchiectasis
Bronchitis, Chronic
Epithelium
Esophagitis, Peptic*
Gastric Juice
Gastroesophageal Reflux
Gastrointestinal Contents
Humans
Inflammation
Lung Diseases*
Lung*
Nontuberculous Mycobacteria
Prevalence*

Figure

• 

  Fig. 1 Study flowchart of nontuberculous mycobacterial lung disease with or without reflux esophagitis. NTM, nontuberculous mycobacteria.

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