Korean J Ophthalmol.  2018 Feb;32(1):52-58. 10.3341/kjo.2016.0127.

Comparison of the Thickness and Volume of the Macula and Fovea in Patients with Anisometropic Amblyopia Prior to and after Occlusion Therapy

• Yoon DH
• Chun BY

• KMID: 2402720
• DOI: http://doi.org/10.3341/kjo.2016.0127

Abstract

PURPOSE
To compare the thickness of superior, temporal, inferior, and nasal macula and foveal thickness and volume in patients with anisometropic amblyopia prior to and after successful occlusion therapy using optical coherence tomography (OCT) measurement.
METHODS
Data were collected prospectively on 30 patients with unilateral anisometropic amblyopia from December 2006 to August 2007. All patients had anisometropia of 2.0 diopters or more. OCT scans were obtained for all patients at diagnosis. Occlusion therapy was then prescribed and OCT scans were obtained again at the time of successful occlusion therapy (defined as interocular difference of <0.1 log units). The Stratus OCT-3 was used to measure fovea thickness and volume and the thickness of superior, temporal, inferior, and nasal macula (within a diameter of 3 mm).
RESULTS
Of 30 patients, 22 (mean age of 5.8 years) had successful resolution of amblyopia. The mean duration of occlusion was 11.24 months and mean best-corrected visual acuity at diagnosis was 0.35 ± 0.12 logarithm of the minimum angle of resolution. The mean thicknesses of the superior, temporal, inferior, and nasal macula prior to and after occlusion were not significantly different (p > 0.05). However, mean foveal volume prior to occlusion therapy (0.15 ± 0.02 mm3) decreased after occlusion (0.14 ± 0.01 mm3) with statistical significance (Wilcoxon signed rank test, p = 0.025).
CONCLUSIONS
There was a meaningful decrease in foveal volume in patients with anisometropic amblyopia after successful occlusion therapy. Whether this decrease relates to visual improvement of the amblyopic eye remains to be determined.

Keyword

Anisometropic amblyopia; Foveal thickness; Foveal volume; Macular thickness; Optical coherence tomography

MeSH Terms

Amblyopia*
Anisometropia
Diagnosis
Humans
Prospective Studies
Tomography, Optical Coherence
Visual Acuity

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