Korean J Urol Oncol.  2017 Dec;15(3):111-120. 10.22465/kjuo.2017.15.3.111.

The Retrospective Analysis of Prognostic Significance of Smoking Status in Bladder Cancer

• Kim SH
• Kim S
• Suh YS
• Kim JK
• Joung JY
• Chung J
• Park WS
• Lee KH
• Seo HK

• KMID: 2402592
• DOI: http://doi.org/10.22465/kjuo.2017.15.3.111

Abstract

PURPOSE
This study aimed to evaluate the prognostic significance of smoking status in muscle invasive bladder cancer (MIBC) and non-MIBC in recurrence-free (RFS), progression-free (PFS), disease-free survival (DFS), and cancer-specific survival (CSS).
MATERIALS AND METHODS
We retrospectively evaluated 541 patients with MIBC and non-MIBC who were surgically treated during 2002-2013. Smoking status was defined as never smokers (NS; n=160, 30%), former smokers (FS; smoking cessation for ≥1 year, n=176, 33%), and current smokers (CS; >100 cigarettes, n=198, 37%). We statistically compared these groups' clinicopathological facCtors for the predictive factors for RFS and PFS for non-MIBC (NMIBC) and DFS for MIBC, and CSS using multivariate model.
RESULTS
The CS, FS, and NS groups exhibited insignificantly different pathological staging, grades, and immunohistological characteristics (p>0.05). Among the 441 patients with NMIBC, pathologic tumor size was a significant risk factor for RFS (1-3 cm: hazard ratio [HR], 1.88; >3 cm: HR, 2.21; p < 0.05); age (HR, 1.06), intravesical therapy (HR, 0.25), and high-grade cancer (HR, 8.33) significant for PFS; and age (HR, 1.08), intravesical instillation (HR, 0.26), and smoking status (FS: HR, 0.40; CS: HR, 0.44) significant for CSS (p < 0.05). The 93 patients with MIBC had no significant risk factors for DFS, although their significant risk factors for CSS were age (HR, 1.05), female sex (HR, 2.64), and carcinoma in situ (HR, 4.72) (p < 0.05).
CONCLUSIONS
Smoking status only significantly affected CSS in patients with NMIBC.

Keyword

Bladder cancer; Muscles; Invasiveness; Smoking; Prognosis

MeSH Terms

Administration, Intravesical
Carcinoma in Situ
Disease-Free Survival
Female
Humans
Muscles
Prognosis
Retrospective Studies*
Risk Factors
Smoke*
Smoking Cessation
Smoking*
Tobacco Products
Urinary Bladder Neoplasms*
Urinary Bladder*
Smoke