Korean J Blood Transfus.  2017 Dec;28(3):304-310. 10.17945/kjbt.2017.28.3.304.

Identification of Anti-G in Pregnant Women with RhD Negative Blood: The First Case in Korea

• Choi S
• Yoon SJ
• Seo JY
• Chun S
• Oh SY
• Cho D

• KMID: 2401749
• DOI: http://doi.org/10.17945/kjbt.2017.28.3.304

Abstract

Anti-G positivity can be misinterpreted as the presence of anti-D or -C antigen in an antibody identification test, as this antibody is known to show agglutination to D or C antigen-positive red cells. Correct identification of anti-G is important in pregnant women, as prenatal care or the need for RhIG administration can vary between anti-D and -C versus anti-G cases. We recently encountered a D-negative case with suspected anti-D and -C, which was ruled out by adsorption and elution tests, and ultimately confirmed the presence of anti-G. The pregnant woman was a 33-year-old patient with cde Rh phenotype with a previous history of spontaneous abortion, followed by administration of RhIG. The spouse's Rh phenotype was CDe. Initial antibody identification test showed 2+ positivity to C (homozygotes and heterozygotes) and trace to 1+ positivity to D. Upon additional adsorption and elution with R0r (cDe/cde) and r'r (Cde/ cde) red cells, we identified the antibody present in the patient's serum as anti-G. The patient is currently under close follow-up monitoring for anti-G titer using antibody titer testing with both CDe and CcDEe red cells. Periodic fetal cerebral Doppler examination is being carried out without evidence of fetal distress.

Keyword

RhD negative; Hemolytic disease of fetus and newborn; Rhogam; Anti-G; Absorption and elution

MeSH Terms

Abortion, Spontaneous
Adsorption
Adult
Agglutination
Female
Fetal Distress
Follow-Up Studies
Humans
Korea*
Phenotype
Pregnancy
Pregnant Women*
Prenatal Care
Rho(D) Immune Globulin
Rho(D) Immune Globulin