J Breast Cancer.  2017 Dec;20(4):404-407. 10.4048/jbc.2017.20.4.404.

Ectopic Male Breast Cancer in the Perineum: A Case Report

• Eom HJ
• Ko BS
• Song IH
• Gong G
• Kim HH

• KMID: 2398212
• DOI: http://doi.org/10.4048/jbc.2017.20.4.404

Abstract

Ectopic breast tissue and male breast cancer are both very rare diseases with only a few reports in the literature. Here, we present the first case of ectopic male breast cancer in the perineum. The patient was a 70-year-old man with a palpable mass in the perineum. A wide local excision and inguinal lymph node dissection revealed invasive breast carcinoma of no special type involving the skin and subcutis, and inguinal lymph node metastases. Immunohistochemical staining showed that the tumor cells were strongly positive for estrogen and progesterone receptors and negative for human epidermal growth factor receptor 2. Moreover, no p53 overexpression was observed. Herein, the clinical and pathologic features, as well as a review of ectopic male breast cancer are discussed.

Keyword

Ectopic breast tissue; Male breast neoplasms; Mammary gland; Perineum

MeSH Terms

Aged
Breast
Breast Neoplasms
Breast Neoplasms, Male*
Estrogens
Humans
Lymph Node Excision
Lymph Nodes
Male
Male*
Mammary Glands, Human
Neoplasm Metastasis
Perineum*
Rare Diseases
Receptor, Epidermal Growth Factor
Receptors, Progesterone
Skin
Estrogens
Receptor, Epidermal Growth Factor
Receptors, Progesterone

Figure

• 

  Figure 1 Computed tomography (CT) and positron emission tomography-CT (PET-CT) images of the inguinal lymph nodes. (A) An enlarged necrotic lymph node is in the left inguinal area. (B) On PET-CT, the lymph node shows hypermetabolism which was diagnosed as a metastatic lymph node after surgical dissection.

• 

  Figure 2 Microscopic findings of the surgical specimen in the perineum. (A) Tumor cells are involving dermis, subcutis, and skeletal muscle (×12.5, H&E stain). (B) The overlying skin shows mild acanthosis, and basal pigmentation is increased (×100, H&E stain). (C) High magnification shows tumor cells arranged in nests with lumen formation in the fibrotic stroma and mild pleomorphism, consistent with invasive breast carcinoma of no special type (×400, H&E stain). (D) Tumor cells are strongly immunoreactive for estrogen receptor (ER), which also suggests the diagnosis of breast carcinoma (×200, ER immunohistochemical staining).

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