Neonatal Med.  2017 Nov;24(4):178-181. 10.5385/nm.2017.24.4.178.

Association of Immunoglobulin G at Birth with Late-Onset Sepsis and Related Mortality in Very Low Birth Weight Infants

• Yun HR
• Shin JM
• Yoon YM
• Shin JS
• Kim JH
• Cho H
• Shin SH
• Kim EK
• Kim HS

• KMID: 2396833
• DOI: http://doi.org/10.5385/nm.2017.24.4.178

Abstract

PURPOSE
We aimed to evaluate the association between immunoglobulin G (IgG) at birth and late-onset sepsis (LoS) in preterm infants.
METHODS
Medical records of very-low-birth-weight infants, born at gestational age <28 weeks, between 2013 and 2016, were retrospectively reviewed. Subjects were divided into two groups based on the occurrence of LoS (LoS vs. non-LoS), and IgG levels at 1 day, and at 2 weeks and 4 weeks after birth were investigated. IgG levels, other perinatal factors, and clinical factors were compared in the two groups. The relationship between IgG levels and mortality among infants in the LoS group was also analyzed.
RESULTS
A total of 105 infants were analyzed after exclusion of cases with early onset sepsis or death at < 72 hours of life. Gestational age in the LoS group was lower than in the non-LoS group (25.0±1.8 vs. 26.3±1.4 weeks, P=0.004). IgG levels at birth were similar between the two groups (236.4±96.4 vs. 282.0±104.7 mg/dL, P=0.078). Multivariate analysis showed that IgG at birth was not an independent risk factor for LoS. In the LoS group, IgG levels at birth were comparable between survivors and cases involving mortality.
CONCLUSION
IgG levels at birth were not associated with the occurrence of LoS in extremely preterm infants.

Keyword

Immunoglobulin G; Extremely preterm infant; Late-onset sepsis; Gestational age

MeSH Terms

Gestational Age
Humans
Immunoglobulin G*
Immunoglobulins*
Infant*
Infant, Extremely Premature
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight*
Medical Records
Mortality*
Multivariate Analysis
Parturition*
Retrospective Studies
Risk Factors
Sepsis*
Survivors
Immunoglobulin G
Immunoglobulins