Biomol Ther.  2017 Nov;25(6):569-577. 10.4062/biomolther.2017.193.

Potential Immunotherapeutics for Immunosuppression in Sepsis

• Shin J
• Jin M

• KMID: 2395805
• DOI: http://doi.org/10.4062/biomolther.2017.193

Abstract

Sepsis is a syndrome characterized by systemic inflammatory responses to a severe infection. Acute hyper-inflammatory reactions in the acute phase of sepsis have been considered as a primary reason for organ dysfunction and mortality, and advances in emergency intervention and improved intensive care management have reduced mortalities in the early phase. However it has been recognized that increased deaths in the late phase still maintain sepsis mortality high worldwide. Patients recovered from early severe illness are unable to control immune system with sepsis-induced immunosuppression such as immunological tolerance, exhaustion and apoptosis, which make them vulnerable to nosocomial and opportunistic infections ultimately leading to threat to life. Based on strategies to reverse immunosuppression, recent developments in sepsis therapy are focused on molecules having immune enhancing activities. These efforts are focused on defining and revising the immunocompromised status associated with long-term mortality.

Keyword

Sepsis; Immunosuppression; Immune modulators; Immunotherapy; Precision medicine; Theranostics

MeSH Terms

Apoptosis
Critical Care
Emergencies
Humans
Immune System
Immunosuppression*
Immunotherapy
Mortality
Opportunistic Infections
Precision Medicine
Sepsis*
Theranostic Nanomedicine