Radiat Oncol J.  2017 Sep;35(3):249-256. 10.3857/roj.2017.00374.

Treatment outcome and risk analysis for cataract after radiotherapy of localized ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma

• Park HH
• Lee SW
• Sung SY
• Choi BO

• KMID: 2393555
• DOI: http://doi.org/10.3857/roj.2017.00374

Abstract

PURPOSE
We retrospectively reviewed the results of radiotherapy for localized ocular adnexal MALT lymphoma (OAML) to investigate the risk factors of cataract.
METHODS
Sixty-seven patients with stage IE OAML treated with radiotherapy at Seoul St. Mary's Hospital from 2001 to 2016 were included. Median treatment dose was 30 Gy. Lens protection was done in 52 (76%) patients. Radiation therapy (RT) extent was as follows: superficial (82.1%), tumor mass (4.5%), and entire orbital socket (13.4%). The risk factors for symptomatic cataract were analyzed using the Cox proportional hazard model.
RESULTS
Median follow-up time was 50.9 months (range, 1.9 to 149.4 months). All patients were alive at the time of analysis. There were 7 recurrences and there was no local recurrence. Median time to recurrence was 40.4 months. There were 14 cases of symptomatic cataract. Dose >30 Gy had hazard ratio of 3.47 for cataract (p = 0.026). Omitting lens protection showed hazard ratio of 4.10 (p = 0.008).
CONCLUSIONS
RT achieves excellent local control of ocular MALT lymphoma. Consideration of RT-related factors such as lens protection and radiation dose at the stage of RT planning may reduce the risk of RT-induced cataract after radiotherapy.

Keyword

Marginal zone B-cell lymphoma; Radiotherapy; Cataract

MeSH Terms

Cataract*
Follow-Up Studies
Humans
Lymphoid Tissue*
Lymphoma*
Lymphoma, B-Cell, Marginal Zone
Orbit
Proportional Hazards Models
Radiotherapy*
Recurrence
Retrospective Studies
Risk Factors
Seoul
Treatment Outcome*