J Pathol Transl Med.  2017 May;51(3):325-328. 10.4132/jptm.2016.09.08.

Clear Cell Renal Cell Carcinoma with Intratumoral Granulomatous Reaction: A Case Report and Review of the Literature

• Kim H
• Kim JW
• Kim A
• Chang H

• KMID: 2392600
• DOI: http://doi.org/10.4132/jptm.2016.09.08

Abstract

Granulomatous reaction associated with clear cell renal cell carcinoma (CCRCC) is a rare finding, and only a few cases have been described in the literature. It is postulated to occur due to cancer-related antigenic factors such as cancer cells themselves or soluble tumor antigens shed into the blood. Herein, we describe a case of a 56-year-old male patient diagnosed with CCRCC with intratumoral granulomatous inflammation.

Keyword

Carcinoma, renal cell; Granulomatous reaction; Kidney neoplasms

MeSH Terms

Antigens, Neoplasm
Carcinoma, Renal Cell*
Humans
Inflammation
Kidney Neoplasms
Male
Middle Aged
Antigens, Neoplasm

Figure

• 

  Fig. 1. Cut surface of the tumor showing yellowish solid mass with surrounding hemorrhagic area.

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  Fig. 2. Several epithelioid granulomas in the clear cell renal cell carcinoma.

• 

  Fig. 3. A granuloma showing a focus of coagulative necrosis.

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