J Pathol Transl Med.  2017 May;51(3):224-241. 10.4132/jptm.2017.04.09.

Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives

Affiliations
  • 1Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. ykjeon@snu.ac.kr
  • 2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
  • 3Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • 4Department of Pathology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
  • 5Department of Pathology, Korea University Guro Hospital, Korea University School of Medicine, Seoul, Korea.
  • 6Department of Pathology, Inje University Sanggye Paik Hospital, Seoul, Korea.
  • 7Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
  • 8Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 9Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B- and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cell-of-origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized.

Keyword

Lymphoproliferative disorders; Malignant lymphoma; Pathology, molecular; Molecular diagnostics; Clonality test; Gene translocation; In situ hybridization, fluorescence; Next-generation sequencing

MeSH Terms

Classification
Cytogenetics
Diagnosis
In Situ Hybridization, Fluorescence
Lymphoma
Lymphoma, B-Cell
Lymphoproliferative Disorders*
Molecular Biology
Pathology, Molecular
T-Lymphocytes
World Health Organization
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