Diabetes Metab J.  2017 Aug;41(4):296-302. 10.4093/dmj.2017.41.4.296.

Depression and Mortality in People with Type 2 Diabetes Mellitus, 2003 to 2013: A Nationwide Population-Based Cohort Study

• Jeong JH
• Um YH
• Ko SH
• Park JH
• Park JY
• Han K
• Ko KS
• Task Force Team for Diabetes Fact Sheet of the Korean Diabetes Association

• KMID: 2392470
• DOI: http://doi.org/10.4093/dmj.2017.41.4.296

Abstract

BACKGROUND
Previous reports have demonstrated a bidirectional relationship between depression and diabetes mellitus (DM), accentuating a need for more intensive depression screening in DM patients. There is a relative paucity of data on the mortality of depressed DM patients in Korea.
METHODS
Retrospective data from January 2003 to December 2013 were collected for adult type 2 diabetes mellitus (T2DM) patients older than 30 years using the National Health Information database maintained by the Korean National Health Insurance Service (NHIS). Demographic characteristics were analyzed with descriptive statistics, and the annual prevalence of depression was estimated. Mortality rates and hazard ratios for each age group (stratified into six age groups) of patients diagnosed with T2DM in 2003 were estimated using a Cox proportional hazard method, with the Kaplan-Meier cumulative survival curve showing the overall survival rates according to the T2DM status until the given year of 2013.
RESULTS
The annual prevalence of depression was consistently higher in T2DM group from 2003 to 2013. The mortality hazard ratio was higher in the depressed in all age groups, and the risk was higher in male groups and in younger-aged groups.
CONCLUSION
Depression was significantly associated with a high mortality risk in T2DM patients; hence, a more systematic surveillance of T2DM patients to identify risk factors for depression might contribute significantly to reducing mortality risk in this group of patients.

Keyword

Depression; Diabetes mellitus; Mortality; Prognosis

MeSH Terms

Adult
Cohort Studies*
Depression*
Diabetes Mellitus
Diabetes Mellitus, Type 2*
Humans
Korea
Male
Mass Screening
Methods
Mortality*
National Health Programs
Prevalence
Prognosis
Retrospective Studies
Risk Factors
Survival Rate

Figure

• 

  Fig. 1 Survival curves for two groups: type 2 diabetes mellitus (T2DM) with depression and T2DM without depression.

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