J Clin Neurol.  2017 Jul;13(3):310-311. 10.3988/jcn.2017.13.3.310.

Severe Paraneoplastic Parkinsonism: A Rare Cause Revealing Breast Cancer

Affiliations
  • 1Department of Neurology, Hôpital Militaire d'instruction Mohamed V, Mohamed V-Souissi University, Rabat, Morocco.
  • 2Research Team in Neurology and Neurogenetics, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco. tibarhouyam@gmail.com
  • 3Neurology B and Neurogenetics Department, Hôpital des Spécialités ONO, CHU Ibn Sina, Rabat, Morocco.
  • 4Pathology Unit, Hôpital Militaire d'instruction Mohamed V, Mohamed V-Souissi University, Rabat, Morocco.

Abstract

No abstract available.


MeSH Terms

Breast Neoplasms*
Breast*
Parkinsonian Disorders*

Figure

  • Fig. 1 A: Sequence of axial brain T2-weighted MRI images showing bilateral hyperintensities in the caudate and putamen. B: Sequence of axial brain T2-weighted MRI images showing no midbrain atrophy. C: Coronal views of PET, whole-body CT, and fused images in a patient with an abnormal hot spot in the upper outer quadrant of the left breast. D: Left-breast biopsy sample with hematoxylin-eosin staining (magnification ×20). Image of high-grade tumor cells showing all the attributes of cytological malignancies: mammary parenchyma widely infiltrated by a carcinomatous process whose architecture is trabecular with a few tumor glands associated with intraductal carcinoma in situ.


Reference

1. Graus F, Delattre JY, Antoine JC, Dalmau J, Giometto B, Grisold W, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry. 2004; 75:1135–1140. PMID: 15258215.
Article
2. Lancaster E. Paraneoplastic disorders. Continuum (Minneap Minn). 2015; 21(2 Neuro-oncology):452–475. PMID: 25837906.
Article
3. Tada S, Furuta M, Fukada K, Hirozawa D, Matsui M, Aoike F, et al. Severe parkinsonism associated with anti-CRMP5 antibody-positive paraneoplastic neurological syndrome and abnormal signal intensity in the bilateral basal ganglia. J Neurol Neurosurg Psychiatry. 2016; 87:907–910. PMID: 26374701.
Article
4. Kannoth S, Anandakkuttan A, Mathai A, Sasikumar AN, Nambiar V. Autoimmune atypical parkinsonism-a group of treatable parkinsonism. J Neurol Sci. 2016; 362:40–46. PMID: 26944115.
5. Golbe LI, Miller DC, Duvoisin RC. Paraneoplastic degeneration of the substantia nigra with dystonia and parkinsonism. Mov Disord. 1989; 4:147–152. PMID: 2543919.
Article
6. Pittock SJ, Lucchinetti CF, Lennon VA. Anti-neuronal nuclear autoantibody type 2: paraneoplastic accompaniments. Ann Neurol. 2003; 53:580–587. PMID: 12730991.
Article
Full Text Links
  • JCN
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr