Korean J Gastroenterol.  2017 Aug;70(2):81-88. 10.4166/kjg.2017.70.2.81.

Associations between Body Mass Index and Chronic Atrophic Gastritis and Intestinal Metaplasia

Affiliations
  • 1Department of Family Medicine, Kyungpook National University School of Medicine, Daegu, Korea. ychfm@knu.ac.kr
  • 2Department of Family Medicine, Kyungpook National University Chilgok Hospital, Daegu, Korea.

Abstract

BACKGROUND/AIMS
Chronic atrophic gastritis (AG) and intestinal metaplasia (IM) of the stomach are premalignant lesions. The present study aimed to examine the associations between obesity and these lesions.
METHODS
A total of 2,997 patients, who underwent gastroscopy, participated in this study, excluding those who had been diagnosed with gastric cancer. Participants were divided into four groups based on their body mass index (BMI). The risk of AG and IM with increasing BMI was analyzed in men and women, separately.
RESULTS
The association between BMI and AG was not significant. After adjusting for age, smoking, alcohol, and AG, the odds ratios for IM in the overweight, obesity, and severe obesity groups were 2.25 (95% confidence interval [CI], 1.50-3.37), 2.32 (95% CI, 1.58-3.42), and 4.86 (95% CI, 2.04-11.5) in men, and 2.66 (95% CI, 1.29-5.47), 4.46 (95% CI, 2.28-8.75), and 9.57 (95% CI, 3.26-28.12) in women, compared with the normal BMI group.
CONCLUSIONS
Gastric IM was significantly associated with increased BMI.

Keyword

Body mass index; Atrophic gastritis; Metaplasia

MeSH Terms

Body Mass Index*
Female
Gastritis, Atrophic*
Gastroscopy
Humans
Male
Metaplasia*
Obesity
Obesity, Morbid
Odds Ratio
Overweight
Smoke
Smoking
Stomach
Stomach Neoplasms
Smoke

Figure

  • Fig. 1. Adjusted mean BMI of patients with AG (A) and IM (B). Values are presented as adjusted mean±standard error. * p-values are from ANCOVA test after adjusting for age, smoking, alcohol intake, and IM. † p-values are from ANCOVA test after adjusting for age, smoking, alcohol intake, and AG. BMI, body mass index, AG, atrophic gastritis, IM, intestinal metaplasia, ANCOVA, analysis of covariance.


Reference

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