Blood Res.  2017 Sep;52(3):224-227. 10.5045/br.2017.52.3.224.

An unusual case of metachronous NK/T cell lymphoma and interdigitating dendritic cell sarcoma

Affiliations
  • 1Division of Medical Oncology, Department of Internal Medicine, Yeouido St Mary's Hospital, College of Medicine, The Catholic University of Korea. yeony86@hanmail.net
  • 2Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 3Division of Hematology-Oncology, Department of Internal Medicine, Cheju Halla General Hospital, Jeju, Korea.

Abstract

No abstract available.


MeSH Terms

Dendritic Cell Sarcoma, Interdigitating*
Dendritic Cells*
Lymphoma*

Figure

  • Fig. 1 Abdominal CT image shows an approximately 4.5 cm-sized low-density mass-like lesion at the Lt external iliac nodal region (A). On sequentially performed PET-CT, increased FDG uptake was identified on the same lesion (B). Two months after diagnosis of NK/T cell lymphoma, follow-up PET-CT revealed extensive multiple hypermetabolic mass on areas including both lungs, spleen, and nasal cavity (C, D).

  • Fig. 2 Histological findings of soft tissue show atypical T-cell proliferation with angiocentric pattern in (A) hematoxylin-eosin stain (×200), and (B) CD3 immunohistochemical (IHC) stain. Additional IHC staining of cancer cells shows positivity for granzyme (C), CD68 (D), and EBV (F) but negativity for CD1a (E). These findings are consistent with nasal type extranodal NK/T cell lymphoma.

  • Fig. 3 Histological findings of cervical lymph node show spindle- to ovoid-shaped cells arranged intermingled with reactive lymphocytes in (A) hematoxylin-eosin stain (×200). IHC staining of cancer cells shows positivity for CD68 (B) and S100 (D) but negativity for CD1a (C) and EBV (F). Intermingled T-lymphocytes within IDCS show positivity for CD3 (E).


Reference

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