Blood Res.  2017 Sep;52(3):224-227. 10.5045/br.2017.52.3.224.

An unusual case of metachronous NK/T cell lymphoma and interdigitating dendritic cell sarcoma

• Hwang SY
• Woo IS
• Chong Y
• Kang CS
• Han CW
• Jung YH

• KMID: 2390988
• DOI: http://doi.org/10.5045/br.2017.52.3.224

Abstract

No abstract available.

MeSH Terms

Dendritic Cell Sarcoma, Interdigitating*
Dendritic Cells*
Lymphoma*

Figure

• 

  Fig. 1 Abdominal CT image shows an approximately 4.5 cm-sized low-density mass-like lesion at the Lt external iliac nodal region (A). On sequentially performed PET-CT, increased FDG uptake was identified on the same lesion (B). Two months after diagnosis of NK/T cell lymphoma, follow-up PET-CT revealed extensive multiple hypermetabolic mass on areas including both lungs, spleen, and nasal cavity (C, D).

• 

  Fig. 2 Histological findings of soft tissue show atypical T-cell proliferation with angiocentric pattern in (A) hematoxylin-eosin stain (×200), and (B) CD3 immunohistochemical (IHC) stain. Additional IHC staining of cancer cells shows positivity for granzyme (C), CD68 (D), and EBV (F) but negativity for CD1a (E). These findings are consistent with nasal type extranodal NK/T cell lymphoma.

• 

  Fig. 3 Histological findings of cervical lymph node show spindle- to ovoid-shaped cells arranged intermingled with reactive lymphocytes in (A) hematoxylin-eosin stain (×200). IHC staining of cancer cells shows positivity for CD68 (B) and S100 (D) but negativity for CD1a (C) and EBV (F). Intermingled T-lymphocytes within IDCS show positivity for CD3 (E).

Reference

1. Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N. Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. Crit Rev Oncol Hematol. 2013; 88:253–271. PMID: 23755890.

2. Vasef MA, Zaatari GS, Chan WC, Sun NC, Weiss LM, Brynes RK. Dendritic cell tumors associated with low-grade B-cell malignancies. Report of three cases. Am J Clin Pathol. 1995; 104:696–701. PMID: 8526215.

3. Cossu A, Deiana A, Lissia A, et al. Synchronous interdigitating dendritic cell sarcoma and B-cell small lymphocytic lymphoma in a lymph node. Arch Pathol Lab Med. 2006; 130:544–547. PMID: 16594749.

4. Feldman AL, Arber DA, Pittaluga S, et al. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. Blood. 2008; 111:5433–5439. PMID: 18272816.

5. Shao H, Xi L, Raffeld M, et al. Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven cases. Mod Pathol. 2011; 24:1421–1432. PMID: 21666687.

6. Chen W, Lau SK, Fong D, et al. High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/ dendritic cell sarcomas. Am J Surg Pathol. 2009; 33:863–873. PMID: 19145200.

7. Miyata-Takata T, Takata K, Yamanouchi S, et al. Detection of T-cell receptor γ gene rearrangement in paraffin-embedded T or natural killer/T-cell lymphoma samples using the BIOMED-2 protocol. Leuk Lymphoma. 2014; 55:2161–2164. PMID: 24308432.

8. O'Malley DP, Agrawal R, Grimm KE, et al. Evidence of BRAF V600E in indeterminate cell tumor and interdigitating dendritic cell sarcoma. Ann Diagn Pathol. 2015; 19:113–116. PMID: 25787243.

9. Ma C, Zhang X, Zhao Y, Wang G, Zhang M. Detection and significance of BRAF gene in mature T/NK cell lymphoma. Zhonghua Zhong Liu Za Zhi. 2015; 37:816–822. PMID: 26887510.

10. Pokuri VK, Merzianu M, Gandhi S, Baqai J, Loree TR, Bhat S. Interdigitating dendritic cell sarcoma. J Natl Compr Canc Netw. 2015; 13:128–132. PMID: 25691604.