Gut Liver.  2017 Sep;11(5):635-641. 10.5009/gnl16397.

Postoperative Helicobacter pylori Infection as a Prognostic Factor for Gastric Cancer Patients after Curative Resection

• Jung DH
• Lee YC
• Kim JH
• Chung H
• Park JC
• Shin SK
• Lee SK
• Kim HI
• Hyung WJ
• Noh SH

• KMID: 2389351
• DOI: http://doi.org/10.5009/gnl16397

Abstract

BACKGROUND/AIMS
Few studies have evaluated the effect of Helicobacter pylori infection on the prognosis of patients diagnosed with gastric cancer (GC) after curative surgery. We investigated the association between the H. pylori infection status and clinical outcome after surgery.
METHODS
We assessed the H. pylori status of 314 patients who underwent curative resection for GC. The H. pylori status was examined using a rapid urease test 2 months after resection. Patients were followed for 10 years after surgery.
RESULTS
An H. pylori infection was observed in 128 of 314 patients. The median follow-up period was 93.5 months. A Kaplan-Meier analysis indicated that patients with H. pylori had a higher cumulative survival rate than those who were negative for H. pylori. Patients with stage II cancer who tested negative for H. pylori were associated with a poor outcome. In a multivariate analysis, H. pylori-negative status was a significant independent prognostic factor for poor overall survival.
CONCLUSIONS
Having a negative H. pylori infection status seems to indicate poor prognosis for patients with GC who have undergone curative resection. Further prospective controlled studies are needed to evaluate the mechanism by which H. pylori affects GC patients after curative surgery in Korea.

Keyword

Helicobacter pylori; Stomach neoplasms; General surgery; Prognosis

MeSH Terms

Follow-Up Studies
Helicobacter pylori*
Helicobacter*
Humans
Kaplan-Meier Estimate
Korea
Multivariate Analysis
Prognosis
Prospective Studies
Stomach Neoplasms*
Survival Rate
Urease
Urease