Ann Dermatol.  2017 Oct;29(5):655-657. 10.5021/ad.2017.29.5.655.

Incidental Focal Acantholytic Dyskeratosis in a Patient with Discoid Lupus Erythematosus: A Possible Role for SPCA1 in the Pathogenesis of the Disease

• Kim HR
• Lim SK
• Lee HE
• Im M
• Lee Y
• Seo YJ
• Lee JH

• KMID: 2388929
• DOI: http://doi.org/10.5021/ad.2017.29.5.655

Abstract

No abstract available.

MeSH Terms

Humans
Lupus Erythematosus, Discoid*

Figure

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  Fig. 1 A slightly elevated, well-demarcated, erythematous round plaque approximately 1 cm in diameter.

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  Fig. 2 (A) Epidermal atrophy, loss of the rete ridge pattern, vacuolar degeneration of basal keratinocytes, and perivascular and perifollicular lymphohistiocyte infiltration, were evident (H&E, ×40). (B) A suprabasilar cleft consisting of acantholytic and dyskeratotic cells was observed (H&E, ×100). The intensity of SERCA2 staining was similar in normal (C) and incidental focal acantholytic dyskeratosis (IFAD) tissue (D). The SPCA1 staining intensity was reduced in IFAD epidermal tissue (F) compared to normal tissue (E) (C, E: normal tissue, D, F: IFAD tissue; ×100).

Reference

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