Gastrointest Interv.  2017 Jul;6(2):94-104. 10.18528/gii.1500342.

Comprehensive management of cholangiocarcinoma: Part II. Treatment

Affiliations
  • 1Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jefflee@mdanderson.org

Abstract

Cholangioarcinoma is a rare but dreadful malignancy which poses much difficulties in the management. If detected early with only localized disease, curative resection is possible. However, most patients present in the late stages of the disease, which are managed with endoscopic biliary drainage and/or chemoradiation. Liver transplantation offers a possibility for cure in the distal and the perihilar tumors for selected candidates. Local treatments, such as hepatic artery-based therapies, brachytherapy, and photodynamic therapy, may offer some benefit in cases of the advanced disease. In this review, we will assess the role of preoperative biliary drainage, how best to drain biliary obstruction, and the intricate details of various treatments that are currently available.

Keyword

Cholangiocarcinoma; Cholestasis; Endoscopic ultrasonography; Liver transplantation; Self expandable metal stents

MeSH Terms

Brachytherapy
Cholangiocarcinoma*
Cholestasis
Drainage
Endosonography
Humans
Liver Transplantation
Photochemotherapy
Self Expandable Metallic Stents
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