Nat Prod Sci.  2017 Jun;23(2):139-145. 10.20307/nps.2017.23.2.139.

Flavonoid Compounds from the Leaves of Kalanchoe prolifera and Their Cytotoxic Activity against P-388 Murine Leukimia Cells

• Aisyah LS
• Yun YF
• Herlina T
• Julaeha E
• Zainuddin
• Nurfarida
• Hidayat AT
• Supratman
• Shiono Y

• KMID: 2387065
• DOI: http://doi.org/10.20307/nps.2017.23.2.139

Abstract

Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin-3-O-β-D-glucopyranoside (3), kaempferol-3-O-β-D-glucopyranoside (4), kaempferol-3-O-α-L-rhamnoside (5), quercetin-3-O-sophoroside (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves of Kalanchoe prolifera. Compounds 1-7 were isolated for first time from this plant. These compounds were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds kaempferol (1) and quercetin (2) showed strongest cytotoxic activity with ICâ‚…â‚€ values of 4.45 ± 0.05 and 6.28 ± 0.02 µg/mL, respectively.

Keyword

Flavonoids; Kalanchoe prolifera; Crassulaceae; P-388 murine leukimia cell

MeSH Terms

Crassulaceae
Flavonoids
In Vitro Techniques
Kalanchoe*
Methanol
Plants
Quercetin
Flavonoids
Methanol
Quercetin

Figure

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  Fig. 1. The structure of compounds 1 – 7 isolated from K. prolifera.

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  Fig. 2. Key HMBC (→) and COSY () correlations of 3.

Reference

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