Obstet Gynecol Sci.  2017 Jul;60(4):369-373. 10.5468/ogs.2017.60.4.369.

Primary mucinous adenocarcinoma of the vulva, intestinal type

• Lee IH
• Kim MK
• Lee YK
• Hong SR
• Lee KH

• KMID: 2386279
• DOI: http://doi.org/10.5468/ogs.2017.60.4.369

Abstract

Primary vulva malignancy is a rare gynecologic malignancy. Most of them are squamous cell carcinomas and adenocarcinomas are much less common. Intestinal type is a rare variant of primary adenocarcinoma of the vulva. It histologically resembles mucinous colonic carcinomas. Origin from cloacal remnants has been suggested but remains speculative. A 64-year-old woman was referred to our clinic with a 1-month history of an itching vulva mass. An incisional biopsy was performed at other hospital and disclosed adenocarcinoma of intestinal type. Extensive workups were performed to detect other underlying carcinomas but revealed nothing abnormal. She underwent wide local excision without lymph node dissection for a primary vulva carcinoma. She received no adjuvant therapy and has been free from recurrent disease for 12 months after surgery. The authors report a rare case and review the relevant literature.

Keyword

Adenocarcinoma, mucinous; Intestinal type; Vulva neoplasms

MeSH Terms

Adenocarcinoma
Adenocarcinoma, Mucinous*
Biopsy
Carcinoma, Squamous Cell
Colon
Female
Humans
Lymph Node Excision
Middle Aged
Mucins*
Pruritus
Vulva*
Vulvar Neoplasms
Mucins

Figure

• 

  Fig. 1 (A) The vulva reveals a reddish dome-like cutaneous mass. (B) The tumor shows an infiltrative mucinous carcinoma and predominant mucin pools. (C) The mucinous carcinoma is intestinal types with presence of characteristically colonic goblet cells (inset) and intracytoplasmic mucin. (D) On immunohistochemical staining the tumor cells show diffuse positive reaction for CEA, (E) cytokeratin 20, and (F) cytokeratin 7.

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