J Breast Dis.  2017 Jun;5(1):28-34. 10.14449/jbd.2017.5.1.28.

Synchronously Diagnosed Gastric Metastasis from Invasive Lobular Breast Carcinoma, Mimicking Primary Gastric Carcinoma

• Shin YD
• Son SM
• Song YJ
• Park SS
• Choi YJ

• KMID: 2385836
• DOI: http://doi.org/10.14449/jbd.2017.5.1.28

Abstract

Gastric metastasis from invasive lobular breast carcinoma is rare. Mostly gastrointestinal metastasis presents as one among multiple metastases, several years after primary diagnosis of breast carcinoma. Herein, we report a synchronously diagnosed gastric metastasis from invasive lobular carcinoma, mimicking primary gastric linitis plastica with pyloric obstruction. We reviewed clinical and pathological findings of gastric carcinoma metastatic from the breast. In particular, we focused on immunohistochemical studies of selected antibodies, including those for estrogen receptors, gross cystic disease fluid protein-15, and caudal-type homeobox transcription factor 2, for accurate differential diagnosis. Clinical suspicion, repeat endoscopic biopsy, and detailed histological analysis including immunohistochemistry are necessary for diagnosis of gastric carcinoma metastatic from the breast.

Keyword

Breast; Carcinoma; Lobular; Neoplasm metastasis; Stomach

MeSH Terms

Antibodies
Biopsy
Breast Neoplasms*
Breast*
Carcinoma, Lobular
Diagnosis
Diagnosis, Differential
Genes, Homeobox
Immunohistochemistry
Linitis Plastica
Neoplasm Metastasis*
Receptors, Estrogen
Stomach
Transcription Factors
Antibodies
Receptors, Estrogen
Transcription Factors