Tuberc Respir Dis.  2017 Jul;80(3):291-295. 10.4046/trd.2017.80.3.291.

Review of Sarcoidosis in a Province of South Korea from 1996 to 2014

Affiliations
  • 1Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea. Kyc0923@jnu.ac.kr
  • 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Abstract

BACKGROUND
Since the introduction of endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) of mediastinal lymph nodes, the incidence of histopathologically-confirmed sarcoidosis has increased.
METHODS
The electronic medical records of Chonnam National University (CNU) Hospital and CNU Hwasun Hospital (CNUHH) were searched for confirmed cases of sarcoidosis diagnosed between 1996 and 2014. Cases were selected using a combination of clinical, radiological, and pathological evidence. Of 115 cases with the relevant disease codes, 16 cases were excluded, as they had not been confirmed pathologically or had no definitive clinical features of sarcoidosis.
RESULTS
Among 99 cases of confirmed sarcoidosis, only nine patients were diagnosed with sarcoidosis before 2008; the rest were diagnosed from 2008 onward, after the introduction of EBUS-TBNA. EBUS-TBNA was used in 75.8% of patients, open surgical biopsy in 13.2%, and mediastinoscopic biopsy in 5.1%. At the time of diagnosis, 42.4% of sarcoidosis cases were at stage I, 55.6% at stage II, and 2% at stage III. Spontaneous remission of sarcoidosis was observed in 33.3% of cases, and stable disease in 37.4%; systemic steroid treatment was initiated in 23.2% of cases. Of the patients treated with systemic steroids, 69.6% showed improvement. The median duration of steroid treatment was 5 months.
CONCLUSION
Following the introduction of EBUS-TBNA, the number of newly diagnosed sarcoidosis patients has increased. Clinical features of sarcoidosis were similar to those previously reported. Spontaneous remission occurred in about one-third of patients, while one-fourth of patients required systemic steroid treatment.

Keyword

Sarcoidosis; Bronchoscopy; Endoscopic Ultrasound-Guided Fine Needle Aspiration

MeSH Terms

Biopsy
Bronchoscopy
Diagnosis
Electronic Health Records
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Humans
Incidence
Jeollanam-do
Korea*
Lymph Nodes
Needles
Remission, Spontaneous
Sarcoidosis*
Steroids
Ultrasonography
Steroids

Figure

  • Figure 1 Number of sarcoidosis cases diagnosed from 1996 to 2014.

  • Figure 2 Kaplan-Meier plot of time to spontaneous remission or progression of sarcoidosis.


Cited by  1 articles

Indirect pathological indicators for cardiac sarcoidosis on endomyocardial biopsy
Myung-Jin Cha, Jeong-Wook Seo, Seil Oh, Eun-Ah Park, Sang-Han Lee, Moon Young Kim, Jae-Young Park
J Pathol Transl Med. 2020;54(5):396-410.    doi: 10.4132/jptm.2020.06.10.


Reference

1. Rybicki BA, Major M, Popovich J Jr, Maliarik MJ, Iannuzzi MC. Racial differences in sarcoidosis incidence: a 5-year study in a health maintenance organization. Am J Epidemiol. 1997; 145:234–241. PMID: 9012596.
Article
2. Bresnitz EA, Strom BL. Epidemiology of sarcoidosis. Epidemiol Rev. 1983; 5:124–156. PMID: 6357818.
3. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999; 160:736–755. PMID: 10430755.
4. Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007; 357:2153–2165. PMID: 18032765.
Article
5. Kim DS, Ahn JJ. Sacoidosis in Korea. Tuberc Respir Dis. 2000; 49:274–280.
Article
6. Scientific Committee in Korean Academy of Tuberculosis and Respiratory Diseases. National survey of sarcoidosis in Korea. Tuberc Respir Dis. 1992; 39:453–473.
7. World Health Organization. International statistical classification of diseases and related health problems. 10th revision. Geneva: World Health Organization;2009.
8. Schemper M, Smith TL. A note on quantifying follow-up in studies of failure time. Control Clin Trials. 1996; 17:343–346. PMID: 8889347.
Article
9. Rybicki BA, Iannuzzi MC, Frederick MM, Thompson BW, Rossman MD, Bresnitz EA, et al. Familial aggregation of sarcoidosis: a case-control etiologic study of sarcoidosis (ACCESS). Am J Respir Crit Care Med. 2001; 164:2085–2091. PMID: 11739139.
10. Hosoda Y, Sasagawa S, Yasuda N. Epidemiology of sarcoidosis: new frontiers to explore. Curr Opin Pulm Med. 2002; 8:424–428. PMID: 12172447.
Article
11. Polychronopoulos VS, Prakash UB. Airway involvement in sarcoidosis. Chest. 2009; 136:1371–1380. PMID: 19892676.
Article
12. Bjermer L, Thunell M, Rosenhall L, Stjernberg N. Endobronchial biopsy positive sarcoidosis: relation to bronchoalveolar lavage and course of disease. Respir Med. 1991; 85:229–234. PMID: 1882112.
Article
13. de Boer S, Milne DG, Zeng I, Wilsher ML. Does CT scanning predict the likelihood of a positive transbronchial biopsy in sarcoidosis? Thorax. 2009; 64:436–439. PMID: 19213774.
Article
14. Descombes E, Gardiol D, Leuenberger P. Transbronchial lung biopsy: an analysis of 530 cases with reference to the number of samples. Monaldi Arch Chest Dis. 1997; 52:324–329. PMID: 9401359.
15. Annema JT, Veselic M, Rabe KF. Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of sarcoidosis. Eur Respir J. 2005; 25:405–409. PMID: 15738281.
16. Gupta D, Dadhwal DS, Agarwal R, Gupta N, Bal A, Aggarwal AN. Endobronchial ultrasound-guided transbronchial needle aspiration vs conventional transbronchial needle aspiration in the diagnosis of sarcoidosis. Chest. 2014; 146:547–556. PMID: 24481031.
Article
17. Dziedzic DA, Peryt A, Orlowski T. The role of EBUS-TBNA and standard bronchoscopic modalities in the diagnosis of sarcoidosis. Clin Respir J. 2017; 11:58–63. PMID: 25919969.
Article
18. Studdy PR, Bird R. Serum angiotensin converting enzyme in sarcoidosis: its value in present clinical practice. Ann Clin Biochem. 1989; 26(Pt 1):13–18. PMID: 2544134.
19. Kim YW. Sarcoidosis. J Korean Med Assoc. 2009; 52:41–48.
Article
20. Baughman RP, Lower EE, Kaufman AH. Ocular sarcoidosis. Semin Respir Crit Care Med. 2010; 31:452–462. PMID: 20665395.
Article
21. Bonfioli AA, Orefice F. Sarcoidosis. Semin Ophthalmol. 2005; 20:177–182. PMID: 16282152.
Article
22. Paramothayan S, Jones PW. Corticosteroid therapy in pulmonary sarcoidosis: a systematic review. JAMA. 2002; 287:1301–1307. PMID: 11886322.
23. Paramothayan NS, Lasserson TJ, Jones PW. Corticosteroids for pulmonary sarcoidosis. Cochrane Database Syst Rev. 2005; (2):CD001114. PMID: 15846612.
Article
Full Text Links
  • TRD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr