Korean J Crit Care Med.  2017 May;32(2):89-105. 10.4266/kjccm.2017.00252.

Status Epilepticus and Beyond: A Clinical Review of Status Epilepticus and an Update on Current Management Strategies in Super-refractory Status Epilepticus

• Poblete R
• Sung G

• KMID: 2384035
• DOI: http://doi.org/10.4266/kjccm.2017.00252

Abstract

Status epilepticus and refractory status epilepticus represent some of the most complex conditions encountered in the neurological intensive care unit. Challenges in management are common as treatment options become limited and prolonged hospital courses are accompanied by complications and worsening patient outcomes. Antiepileptic drug treatments have become increasingly complex. Rational polytherapy should consider the pharmacodynamics and kinetics of medications. When seizures cannot be controlled with medical therapy, alternative treatments, including early surgical evaluation can be considered; however, evidence is limited. This review provides a brief overview of status epilepticus, and a recent update on the management of refractory status epilepticus based on evidence from the literature, evidence-based guidelines, and experiences at our institution.

Keyword

anticonvulsants; intensive care; pharmacokinetics; seizures; status epilepticus

MeSH Terms

Anticonvulsants
Complementary Therapies
Critical Care
Humans
Intensive Care Units
Kinetics
Pharmacokinetics
Seizures
Status Epilepticus*
Anticonvulsants