Korean J Helicobacter Up Gastrointest Res.  2017 Jun;17(2):83-87. 10.7704/kjhugr.2017.17.2.83.

Helicobacter pylori Eradication Rate in Patients with Diabetes

• Yoo J
• Yu YJ
• Cho G
• Oh H
• Oh SH
• Kim TH
• Oh JH

• KMID: 2383586
• DOI: http://doi.org/10.7704/kjhugr.2017.17.2.83

Abstract

BACKGROUND/AIMS
The prevalence of diabetes mellitus is increasing. Little is known about the difference in Helicobacter pylori eradication rates between diabetic patients and non-diabetics. The aim of this study was to compare the eradication rate between diabetic and non-diabetic patients.
MATERIALS AND METHODS
The medical records of patients who received a proton pump inhibitor (PPI)-based eradication therapy between 2012 and 2015 were retrospectively reviewed. All the patients underwent endoscopic biopsy to confirm H. pylori infection. Successful eradication was confirmed by using the ¹³C-urea breath test, biopsy, or rapid urease test, which was performed at least 4 weeks after the end of eradication therapy.
RESULTS
A total of 1,402 patients were included. The eradication rate was 74.3% (1,041/1,402; 95% CI, 72.0~76.5%). Excluding 151 patients who were confirmed to have no diabetes, 182 diabetic and 1,069 non-diabetic patients were compared. No significant difference (P=0.667) in eradication rate with PPI-amoxicillin-clarithromycin therapy was found between the diabetic (75.8%, 138/182; 95% CI, 69.6~82.0%) and non-diabetic groups (74.0%, 791/1,069; 95% CI, 71.4~76.6%). Peptic ulcer was much more common in the diabetic group than in the non-diabetic group (67.0% vs. 57.9%, P=0.038).
CONCLUSIONS
The H. pylori eradication rate with PPI-based triple therapy in the diabetic patients was probably not different from that in non-diabetic patients.

Keyword

Diabetes mellitus; Helicobacter pylori; Prevalence; Retrospective studies

MeSH Terms

Biopsy
Breath Tests
Diabetes Mellitus
Helicobacter pylori*
Helicobacter*
Humans
Medical Records
Peptic Ulcer
Prevalence
Proton Pumps
Retrospective Studies
Urease
Proton Pumps
Urease