Korean J Helicobacter Up Gastrointest Res.  2016 Dec;16(4):221-225. 10.7704/kjhugr.2016.16.4.221.

The Clinical Features and Helicobacter pylori Eradication Therapy in Lymphofollicular Gastritis: A Single Center Experience

• An HJ
• Lee NH
• Kang C
• Song HY
• Yang JS
• Kim EJ
• Seo YH

• KMID: 2383563
• DOI: http://doi.org/10.7704/kjhugr.2016.16.4.221

Abstract

BACKGROUND/AIMS
Lymphofollicular gastritis (LFG) is defined as antral gastritis with endoscopic findings characterized by a miliary pattern resembling "goose flesh". We aimed to analyze the clinical features of LFG and the utility of Helicobacter pylori eradication therapy in LFG.
MATERIALS AND METHODS
Patients with LFG, regardless of upper gastrointestinal symptoms (7 men, 28 women; age range, 21~67 years), were examined for H. pylori using the CLO test during endoscopy. One specimen was obtained from the greater curvatures of the lower body and the antrum. Clinical features were compared according to H. pylori-positive status.
RESULTS
Among 35 patients with LFG, 31 (88.6%) were infected with H. pylori. LFG predominantly affected young women (28/35, 80.0%; mean age, 43.73 years). One case of gastric cancer with H. pylori-positive LFG was found. H. pylori eradication rate in LFG patients was low (3/12, 25.0%).
CONCLUSIONS
LFG is closely associated with H. pylori infection and predominantly affects women and young adults. Future studies are needed to determine whether H. pylori eradication reduces the risk of gastric cancer.

Keyword

Lymphofollicular gastritis; Helicobacter pylori; Eradication therapy

MeSH Terms

Endoscopy
Female
Gastritis*
Helicobacter pylori*
Helicobacter*
Humans
Male
Stomach Neoplasms
Young Adult