Korean J Gastroenterol.  2016 Nov;68(5):260-264. 10.4166/kjg.2016.68.5.260.

Eradication Rate by Duration of Third-line Rescue Therapy with Levofloxacin after Helicobacter pylori Treatment Failure in Clinical Practice

• Noh HM
• Hong SJ
• Han JP
• Park KW
• Lee YN
• Lee TH
• Ko BM
• Lee JS
• Lee MS

• KMID: 2383503
• DOI: http://doi.org/10.4166/kjg.2016.68.5.260

Abstract

BACKGROUND/AIMS
This study evaluated the eradication rate of levofloxacin-containing rescue therapy by treatment duration in patients in whom previous first- and second-line treatment failed.
METHODS
Fifty-five patients with persistent Helicobacter pylori infection after first-line therapy and second-line therapy were studied in a single referral academic center. We compared the eradication rates by the treatment duration of third-line therapy.
RESULTS
Of 55 patients, 12 (21.8%) received rescue therapy for seven days, 24 (43.6%) received rescue therapy for 10 days, and 19 (34.5%) received rescue therapy for 14 days. The eradication rates of therapy with levofloxacin were 65.5% in the 55 enrolled patients and 73.5% in the 49 patients who underwent follow-up testing. In cases where follow-up testing was performed, the eradication rate of 7-day therapy was 58.3%, of 10-day 68.2%, and of 14-day therapy 93.3%. Eradication rate of 14-day therapy was higher than 7-day (p=0.06) and 10-day (p=0.108), but chance could not be ruled out in the difference among groups.
CONCLUSIONS
This study showed somewhat increasing of H. pylori eradication rate by extending the duration of levofloxacin-containing rescue therapy to 14 days.

Keyword

Helicobacter pylori; Eradication; Levofloxacin; Rescue therapy

MeSH Terms

Follow-Up Studies
Helicobacter pylori*
Helicobacter*
Humans
Levofloxacin*
Referral and Consultation
Treatment Failure*

Figure

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  Fig. 1. Study flowchart.

Reference

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