J Korean Neuropsychiatr Assoc.  2014 Nov;53(6):386-393. 10.4306/jknpa.2014.53.6.386.

Relationship of Suicide Risk with Early Life Stress and Resilience in Patients with Major Depressive Disorder

• Huh K
• Choi WJ
• Seok JH

• KMID: 2383328
• DOI: http://doi.org/10.4306/jknpa.2014.53.6.386

Abstract

OBJECTIVES
The aim of this study is to investigate the relationship of suicide risk with early-life stress (ELS) and resilience in patients with major depressive disorder (MDD).
METHODS
The participants were 60 patients with MDD and 29 healthy volunteers. Each subject was assessed concerning ELS, resilience factors, suicide ideation, and depressive symptom severity using self-report questionnaires. Mann-Whitney test and stepwise multiple linear regression analyses were performed.
RESULTS
Emotional abuse, physical abuse, neglect, and exposure to inter-parental violence were higher in the patient group than in the control group. Resilience factors were significantly lower in the patient group. In multiple regression analyses, final regression model including physical abuse, neglect, and self-regulation factor was significant explaining 45.6% variance of suicide ideation score.
CONCLUSION
We found that ELS experiences, particularly exposure to inter-parental violence, might be a significant risk factor for development of depression. In particular, experiences of physical abuse and neglect might increase the risk of suicide in depression but resilience may play a protective role in development of depression and prevention of suicide in depressive patients.

Keyword

Early-life stress; Resilience; Suicide; Major depressive disorder

MeSH Terms

Depression
Depressive Disorder, Major*
Healthy Volunteers
Humans
Linear Models
Surveys and Questionnaires
Risk Factors
Stress, Psychological*
Suicide*
Violence

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