Obstet Gynecol Sci.  2017 Jan;60(1):133-137. 10.5468/ogs.2017.60.1.133.

Pregnancy-related osteoporosis and spinal fractures

• Yun KY
• Han SE
• Kim SC
• Joo JK
• Lee KS

• KMID: 2383222
• DOI: http://doi.org/10.5468/ogs.2017.60.1.133

Abstract

Pregnancy-related osteoporosis is a very rare condition characterized by the occurrence of fracture during pregnancy or the puerperium. Despite its relative rarity, it can be a dangerous condition that causes severe back pain, height loss and disability. Normal physiologic changes during pregnancy, genetic or racial difference, obstetrical history and obstetrical disease, such as preterm labor or pregnancy-induced hypertension, are presumed risk factors of pregnancy-related osteooporosis. However, exact etiology and pathogenesis are uncertain. The management and natural history are still poorly defined. Traditional medications for osteoporosis are calcium/vitamin D and bisphosphonate. Concerns with bisphosphonate include accumulation in bone and fetal exposure in subsequent pregnancies. The newly developed medication, teriparatide, has shown good results. We report six cases of pregnancy-related osteoporosis and spinal fracture with literature review.

Keyword

Fractures; compression; Osteoporosis; Pregnancy

MeSH Terms

Back Pain
Female
Hypertension, Pregnancy-Induced
Natural History
Obstetric Labor, Premature
Osteoporosis*
Postpartum Period
Pregnancy
Risk Factors
Spinal Fractures*
Teriparatide
Teriparatide

Figure

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  Fig. 1 (A,B) Vertebral compression fractures in magnetic resonance imaging in case 3.

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