J Korean Radiol Soc.  1993 Oct;29(5):853-860.

In vivo H MR spectroscopy of human brain in six normal volunteers

• Choe BY
• Suh TS
• Bahk YW
• Shinn KS

Abstract

In vivo 1H MR spectroscopic studies were performed on the human brain in six normal volunteers. Some distinct proton metabolites, such as N-acetylaspartate (NAA), creatine/phosphoccreatine (Cr), choline/phosphocholine (Cho), myo-inostitol (Ins) and lipid (fat) were clearly identified in normal brain tissues. The signal intensity of NAA resonance is strongest. The standard ratios of metabolites from the normal brain tissues in specific regions were obtained for the references of further in vivo 1H MR spectroscopic studies. Our initial results suggest the in vivo 1H MR spectroscopy may provide more precise diagnosis on the basis of the metabolic informations on brain tissues. The unique ability of in vivo 1H MR spectroscopy to offer noninvasive information about tissue biochemistry in patients will stimulate its impact on clinical research and disease diagnosis.

MeSH Terms

Biochemistry
Brain*
Diagnosis
Healthy Volunteers*
Humans*
Magnetic Resonance Spectroscopy*
Protons
Protons