Ann Dermatol.  1999 Oct;11(4):263-266. 10.5021/ad.1999.11.4.263.

A Case of Cutaneous Ossification occurring in Pseudohypoparathyroidism

• Ahn H
• Kim KS
• Kim IH
• Song HJ
• Cheon HW
• Lee JW
• Oh CH

• KMID: 2383037
• DOI: http://doi.org/10.5021/ad.1999.11.4.263

Abstract

In Albright's hereditary osteodystrophy (AHO) including the syndromes of pseudohypoparathyroidism (PHP) and pseudopseudohypoparathyroidism (PPHP), multiple areas of intracutaneous ossification are often encountered. The characteristic features are short stature, round face, short neck, obesity, cutaneous ossifications, and various skeletal anomalies including short metacarpal and metatarsal bones, curve of radius, and brachydactyly. The patient was a 10-month-old male infant. He presented slightly depressed erythematous hard plaques on the left upper chest and left thigh. We had taken biopsies from both skin lesions, confirming cutaneous ossification or bone formation. He also had the characteristic features of AHO. He had a history of admission due to patent ductus arteriosus and atrial septal defect. The laboratory results showed slightly decreased calcium, increased phosphorus and PTH levels. The patient received no specific corrective measures because his calcium and phosphorus levels were not far from normal values until newly developed similar skin lesions appeared.

Keyword

Cutaneous ossification; Pseudohypoparathyroidism

MeSH Terms

Biopsy
Brachydactyly
Calcium
Ductus Arteriosus, Patent
Heart Septal Defects, Atrial
Humans
Infant
Male
Metatarsal Bones
Neck
Obesity
Osteogenesis
Phosphorus
Pseudohypoparathyroidism*
Pseudopseudohypoparathyroidism
Radius
Reference Values
Skin
Thigh
Thorax
Calcium
Phosphorus