Ann Dermatol.  1999 Oct;11(4):255-259. 10.5021/ad.1999.11.4.255.

A Case of Reticulohistiocytoma

• Cho S
• Lim YS
• Choi HY
• Myung KB

• KMID: 2383035
• DOI: http://doi.org/10.5021/ad.1999.11.4.255

Abstract

Reticulohistiocytoma, a rare form of non-Langerhans cell histiocytoses, usually presents it-self as a single cutaneous nodule mainly on the head and neck of young men without associated arthritis. We describe an 18-year-old male patient with a red dome-shaped nodule of 2 months' duration on the scalp. Histologic examination of the excised mass revealed numerous large, mononucleated or multinucleated histiocytes with abundant eosinophilic, finely granular cytoplasm having a ground-glass appearance. Immunohistochemical staining was positive for vimentin, lysozyme, and factor XIIIa, supporting a dermal dendrocyte lineage. Ultrastructurally, large mononuclear or multinucleated cells exhibiting numerous peripheral villi contained pleomorphic cytoplasmic inclusions, fatty droplets and dense bodies. Our clinicopathologic findings support the concept that reticulohistiocytoma is a variant of adult xanthogranuloma.

Keyword

Reticulohistiocytoma; Ground-glass cytoplasm; Dermal dendrocyte; Xanthogranuloma

MeSH Terms

Adolescent
Adult
Arthritis
Cytoplasm
Eosinophils
Factor XIIIa
Head
Histiocytes
Histiocytosis
Histiocytosis, Non-Langerhans-Cell*
Humans
Inclusion Bodies
Male
Muramidase
Neck
Scalp
Vimentin
Factor XIIIa
Muramidase
Vimentin