Asian Spine J.  2016 Jun;10(3):407-413. 10.4184/asj.2016.10.3.407.

Effects of Systemic and Local Interferon Beta-1a on Epidural Fibrosis

Affiliations
  • 1Department of Neurosurgery, Uludag University Medical School, Bursa, Turkey. ozgurt@uludag.edu.tr
  • 2Department of Pathology, Uludag University Medical School, Bursa, Turkey.
  • 3Department of Biostatistics, Uludag University Medical School, Bursa, Turkey.

Abstract

STUDY DESIGN: Level 1 randomized controlled study. PURPOSE: To investigate the effects of systemic and local interferon-beta-1a (IFN-β-1a) on prevention of epidural fibrosis using histopathological parameters. OVERVIEW OF LITERATURE: Epidural fibrosis involves fibroblastic invasion of nerve roots into the epidural space. Formation of dense fibrous tissue causes lumbar and radicular pain. Many surgical techniques and several materials have been proposed in the literature, but no study has assessed the effect of IFN-β-1a on prevention of epidural fibrosis.
METHODS
Forty-eight adult female Sprague-Dawley rats were divided into six groups of eight: sham group, control group, systemic 44 μg IFN-β-1a group and 22 μg IFN-β-1a group (after laminectomy and discectomy, 0.28 mL and 0.14 mL IFN-β-1a applied subcutaneously three times for a week, respectively), local 44 μg IFN-β-1a group (laminectomy and discectomy, followed by 0.28 mL IFN-β-1a on the surgical area), and local 22 μg IFN-β-1a group (laminectomy and discectomy, followed by 0.14 mL IFN-β-1a on the surgical area). All rats were sacrificed after 4 weeks and groups were evaluated histopathologically.
RESULTS
Compared with sham and control groups, significantly less epidural fibrosis, dural adhesion, and fibroblast cell density were observed in the local and systemic 44 μg IFN-β-1a groups. No other differences were evident between the local and systemic groups.
CONCLUSIONS
IFN-β-1a is effective in preventing epidural fibrosis with systemic and local application.

Keyword

Fibrosis; Interferon beta-1a; Laminectomy

MeSH Terms

Adult
Animals
Cell Count
Control Groups
Diskectomy
Epidural Space
Female
Fibroblasts
Fibrosis*
Humans
Interferon beta-1a*
Interferons*
Laminectomy
Rats
Rats, Sprague-Dawley
Interferon beta-1a
Interferons
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