Gut Liver.
2016 Jan;10(1):95-100. 10.5009/gnl14363.
Complications Requiring Hospital Admission and Causes of In-Hospital Death over Time in Alcoholic and Nonalcoholic Cirrhosis Patients
- Affiliations
-
- 1Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. cwkim@catholic.ac.kr
- 2Department of Internal Medicine, International St. Mary's Hospital, Incheon, Korea.
- 3Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.
- 4Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.
- 5Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
- 6Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea.
- KMID: 2382349
- DOI: http://doi.org/10.5009/gnl14363
Abstract
- BACKGROUND/AIMS
Data on the epidemiology of alcoholic cirrhosis, especially in Asian countries, are limited. We compared the temporal evolution of patterns of alcoholic and nonalcoholic cirrhosis over the last decade.
METHODS
We retrospectively examined the inpatient datasets of five referral centers during 2002 and 2011. The study included patients who were admitted due to specific complications of liver cirrhosis. We compared the causes of hospital admissions and in-hospital deaths between patients with alcoholic and nonalcoholic cirrhosis.
RESULTS
Among the included 2,799 hospitalizations (2,165 patients), 1,496 (1,143 patients) were from 2002, and 1,303 (1,022 patients) were from 2011. Over time, there was a reduction in the rate of hepatic encephalopathy (HE) as a cause of hospitalization and an increase in the rate of hepatocellular carcinoma. Deaths that were attributable to HE or spontaneous bacterial peritonitis (SBP) significantly decreased, whereas those due to hepatorenal syndrome (HRS) significantly increased over time in patients with alcoholic cirrhosis. However, in patients with nonalcoholic cirrhosis, hepatic failure and HRS remained the principal causes of in-hospital death during both time periods.
CONCLUSIONS
The major causes of in-hospital deaths have evolved from acute cirrhotic complications, including HE or SBP to HRS in alcoholic cirrhosis, whereas those have remained unchanged in nonalcoholic cirrhosis during the last decade.
MeSH Terms
-
Aged
Asia/epidemiology
Bacterial Infections/etiology/mortality
Carcinoma, Hepatocellular/etiology/mortality
Cause of Death
Female
Hepatic Encephalopathy/etiology/mortality
Hepatorenal Syndrome/etiology/mortality
Hospital Mortality/*trends
Hospitalization/*trends
Humans
Liver Cirrhosis/*complications/mortality
Liver Cirrhosis, Alcoholic/*complications/mortality
Liver Neoplasms/etiology/mortality
Male
Middle Aged
Peritonitis/microbiology/mortality
Retrospective Studies
Risk Factors
Time Factors
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