Gut Liver.  2016 Jan;10(1):58-62. 10.5009/gnl14127.

Clinical Risk Factors for Upper Gastrointestinal Bleeding after Percutaneous Coronary Intervention: A Single-Center Study

• Lee JM
• Park SY
• Choi JH
• Kim UJ
• Rew SJ
• Cho JY
• Ahn Y
• Lim SW
• Jun CH
• Park CH
• Kim HS
• Choi SK
• Rew JS

• KMID: 2382344
• DOI: http://doi.org/10.5009/gnl14127

Abstract

BACKGROUND/AIMS
Percutaneous coronary intervention (PCI) is often performed therapeutically, and antithrombotic treatment is required for at least 12 months after stent implantation. However, the development of post-PCI upper gastrointestinal bleeding (UGIB) increases morbidity and mortality. We investigated the incidence and risk factors for UGIB in Korean patients within 1 year after PCI.
METHODS
The medical records of 3,541 patients who had undergone PCI between January 2006 and June 2012 were retrospectively reviewed. We identified 40 cases of UGIB. We analyzed the incidence and clinical risk factors associated with UGIB occurring within 1 year after PCI by comparing the results for each case to matched controls. The propensity score matching method using age and sex was utilized.
RESULTS
UGIB occurred in 40 patients (1.1%). Two independent risk factors for UGIB were a history of peptic ulcer disease (odds ratio [OR], 12.68; 95% confidence interval [CI], 2.70 to 59.66; p=0.001) and the use of anticoagulants (OR, 7.76; 95% CI, 2.10 to 28.66; p=0.002).
CONCLUSIONS
UGIB after PCI occurred at a rate of 1.1% in the study population. Clinicians must remain vigilant for the possibility of UGIB after PCI and should consider performing timely endoscopy in patients who have undergone PCI and are suspected of having an UGIB.

Keyword

Gastrointestinal hemorrhage; Percutaneous coronary intervention; Esophagogastroduodenoscopy

MeSH Terms

Aged
Anticoagulants/adverse effects
Case-Control Studies
Female
Gastrointestinal Hemorrhage/epidemiology/*etiology
Humans
Incidence
Male
Middle Aged
Peptic Ulcer/complications
Percutaneous Coronary Intervention/*adverse effects
*Postoperative Complications
Propensity Score
Republic of Korea/epidemiology
Retrospective Studies
Risk Factors
Anticoagulants