Korean J Intern Med.  2015 Nov;30(6):821-828. 10.3904/kjim.2015.30.6.821.

Temporal trends and in-hospital outcomes of primary percutaneous coronary intervention in nonagenarians with ST-segment elevation myocardial infarction

• Kim JY
• Jeong MH
• Choi YW
• Ahn YK
• Chae SC
• Hur SH
• Hong TJ
• Kim YJ
• Seong IW
• Chae IH
• Cho MC
• Yoon JH
• Seung KB
• Other Korea Acute Myocardial Infarction Registry Investigators

• KMID: 2381586
• DOI: http://doi.org/10.3904/kjim.2015.30.6.821

Abstract

BACKGROUND/AIMS
Data regarding the outcomes of primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) in nonagenarians are very limited. The aim of the present study was to evaluate the temporal trends and in-hospital outcomes of primary PCI in nonagenarian STEMI patients.
METHODS
We retrospectively reviewed data from the Korea Acute Myocardial Infarction Registry (KAMIR) from November 2005 to January 2008, and from the Korea Working Group on Myocardial Infarction (KorMI) from February 2008 to May 2010.
RESULTS
During this period, the proportion of nonagenarians among STEMI patients more than doubled (0.59% in KAMIR vs. 1.35% in KorMI), and the rate of use of primary PCI also increased (from 62.5% in KAMIR to 81.0% in KorMI). We identified 84 eligible study patients for which the overall in-hospital mortality rate was 21.4% (25.0% in KAMIR vs. 20.3% in KorMI, p = 0.919). Multivariate analysis identified two independent predictors of in-hospital mortality, namely a final Thrombolysis in Myocardial Infarction (TIMI) flow < 3 (odds ratio [OR], 13.7; 95% confidence interval [CI], 3.2 to 59.0; p < 0.001) and cardiogenic shock during hospitalization (OR, 6.7; 95% CI, 1.5 to 30.3; p = 0.013).
CONCLUSIONS
The number of nonagenarian STEMI patients who have undergone primary PCI has increased. Although a final TIMI flow < 3 and cardiogenic shock are independent predictors of in-hospital mortality, primary PCI can be performed with a high success rate and an acceptable in-hospital mortality rate.

Keyword

In-hospital outcomes; Aged, 90 and over; Myocardial infarction; Percutaneous coronary intervention

MeSH Terms

Age Factors
Aged, 80 and over
Chi-Square Distribution
Female
Hospital Mortality/trends
Humans
Logistic Models
Male
Multivariate Analysis
Myocardial Infarction/diagnosis/mortality/*therapy
Odds Ratio
Percutaneous Coronary Intervention/adverse effects/mortality/*trends
Registries
Republic of Korea
Retrospective Studies
Risk Factors
Shock, Cardiogenic/etiology
Time Factors
Treatment Outcome