Kidney Res Clin Pract.
2015 Jun;34(2):113-116. 10.1016/j.krcp.2014.09.006.
A rare case of hyperoxaluria presenting with acute liver injury and stone-free kidney injury
- Affiliations
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- 1Department of Internal Medicine, National Medical Center, Seoul, Korea.
- 2Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea.
- 3Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- 4Division of Nephrology, Department of Internal Medicine, National Medical Center, Seoul, Korea. reginaprayer@gmail.com
- KMID: 2381527
- DOI: http://doi.org/10.1016/j.krcp.2014.09.006
Abstract
- A 49-year-old woman visited the clinic because of acute hepatitis and acute kidney injury with decreased urine output presenting microscopic hematuria and proteinuria. An abdominal computed tomography revealed a localized, hypoattenuated lesion in a hepatic lateral segment, and kidney biopsy showed oxalate crystal deposition with tubular necrosis. In addition, the patient's 24-hour urinary excretion of oxalate was increased. Her kidney and liver injury improved after sessions of hemodialysis, and urinary oxalate excretion was normalized. Major mutations in primary hyperoxaluria have not been proven. A full sequencing of target genes may be helpful to diagnose a rare form of primary hyperoxaluria.
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