J Pathol Transl Med.  2015 Sep;49(5):421-423. 10.4132/jptm.2015.05.19.

Gastric Langerhans Cell Histiocytosis: Case Report and Review of the Literature

• Lee SJ
• Hwang CS
• Huh GY
• Lee CH
• Park DY

• KMID: 2381400
• DOI: http://doi.org/10.4132/jptm.2015.05.19

Abstract

No abstract available.

MeSH Terms

Histiocytosis, Langerhans-Cell*

Figure

• 

  Fig. 1. Endoscopic and histologic finding of gastric Langerhans cell histiocytosis. (A) A mild elevated mucosal lesion (1 cm in size) with central erosion is observed upon gastroenteroscopy (circle). The lesion is located in the fundus of the stomach. (B) Microscopic analysis of the endoscopic submucosal dissection specimen. Focal histiocytic cell aggregates are present in the lamina propria and muscularis mucosa, with abundant eosinophils and other inflammatory cells. (C) Microscopic analysis of the endoscopic biopsy specimen reveals histiocytic cell aggregates in the lamina propria of the mucosa, with abundant eosinophil infiltration. Lymphocytes and plasma cells are also observed. The histiocytic cells show an irregular nuclear membrane and groove. These cells have abundant and granular eosinophilic to clear cytoplasm. (D) Immunohistochemistry for CD1a. The histiocytic cells show positive staining for CD1a.

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