J Pathol Transl Med.  2015 Mar;49(2):144-147. 10.4132/jptm.2014.02.10.

Oncocytic Lipoadenoma: A Rare Case of Parotid Gland Tumor and Review of the Literature

• Chi CL
• Kuo TT
• Lee LY

• KMID: 2381369
• DOI: http://doi.org/10.4132/jptm.2014.02.10

Abstract

Oncocytic lipoadenoma is a rare tumor, with only 18 cases having been reported since the first in 1998. We encountered a case of oncocytic lipoadenoma presenting as a slowly growing parotid mass in a 71-year-old man. This tumor is characteristically comprised of a mixture of oncocytes and adipocytes. The present case is one of five reported cases of oncocytic lipoadenoma showing sebaceous differentiation. The results of immunohistochemical study with DOG1 antibody supported the origination of this tumor in the striated duct.

Keyword

Parotid gland; Lipoadenoma; Oncocytic cell; Sebaceous differentiation; DOG1

MeSH Terms

Adipocytes
Aged
Humans
Oxyphil Cells
Parotid Gland*

Figure

• 

  Fig. 1. Oncocytic lipoadenoma. (A) Computed tomography reveals a heterogeneous tumor with a fat component (arrow). (B) Grossly, the cut surface is a mixture of tan and yellow components. (C) The scanning view shows an encapsulated tumor with biphasic components and surrounded by normal acini.

• 

  Fig. 2. (A) Oncocytic cells are arranged in an acinar or glandular pattern. (B) The arrows indicate foci of sebaceous differentiation. DOG1 expression is seen in normal parotid acinar cells (C) but not oncocytic cells (D).

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