Korean J Dermatol.  2017 May;55(4):249-252.

Multiple Giant Keratoacanthoma Treated with Acitretin

• Kwon ES
• Lee KG
• Koh BY
• Myung KB
• Cheong SH

Abstract

Giant keratoacanthoma is an uncommon variant of keratoacanthoma, which may increase to a diameter of several centimeters. Although keratoacanthomas usually resolve spontaneously, giant keratoacanthoma can be invasive and destructive. A 49-year-old man presented with a 5-year history of multiple large hyperkeratotic and crusted plaques and nodules on sun-exposed areas such as the face, ear, hand, and forearm. Some lesions involuted spontaneously, whereas others became rather enlarged. The biopsy specimen revealed horn-filled crater formation, epidermal extending resembling a buttress, and an eosinophilic glassy appearance in the keratinocytic cytoplasm. We treated the lesions with acitretin, and they almost completely resolved after 13 weeks. Here we describe a case of multiple giant keratoacanthoma treated with acitretin.

Keyword

Acitretin; Giant keratoacanthoma; Keratoacanthoma

MeSH Terms

Acitretin*
Biopsy
Cytoplasm
Ear
Eosinophils
Forearm
Hand
Humans
Keratoacanthoma*
Middle Aged
Acitretin