J Korean Geriatr Psychiatry.  2017 Apr;21(1):41-45. 10.0000/jkgp.2017.21.1.41.

A Case of Treatment of Delayed Encephalopathy after Acute Carbon Monoxide Intoxication

• Lee SH
• Jhoo JH

• KMID: 2379254
• DOI: http://doi.org/10.0000/jkgp.2017.21.1.41

Abstract

Delayed carbon monoxide (CO) encephalopathy patients can show cognitive impairment, aphasia, affective and personality changes and behavioral symptoms. The prognosis of them is sometimes poor or irreversible. We present a case of 61-year-old woman who visited us at 56 days after CO intoxication and showed moderate to severe cognitive impairment and behavioral problems. We prescribed the donepezil (5 mg/d), memantine (5 mg/d), choline alfoscerate (800 mg/d) and ziprasidone (20 mg/d), based on previous case reports and performed the cognitive rehabilitation. After 30 days treatment in hospital, she showed dramatic improvement in cognitive functions and behavioral problems. This case suggests that adequate pharmacological and cognitive treatment could improve the moderate to severe symptoms of delayed CO encephalopathy even about 2 months later after CO intoxication.

Keyword

Carbon monoxide; Encephalopathy; Treatment

MeSH Terms

Aphasia
Behavioral Symptoms
Brain Diseases*
Carbon Monoxide*
Carbon*
Cognition
Cognition Disorders
Female
Glycerylphosphorylcholine
Humans
Memantine
Middle Aged
Problem Behavior
Prognosis
Rehabilitation
Carbon
Carbon Monoxide
Glycerylphosphorylcholine
Memantine