Korean J Neurotrauma.  2015 Oct;11(2):139-143. 10.13004/kjnt.2015.11.2.139.

Isolated Adrenocorticotropic Hormone or Thyrotropin Deficiency Following Mild Traumatic Brain Injury: Three Cases with Long-Term Follow-Up

• Baek CO
• Kim YJ
• Kim JH
• Park JH

• KMID: 2378273
• DOI: http://doi.org/10.13004/kjnt.2015.11.2.139

Abstract

Few studies have examined the clinical features and long-term outcomes of isolated pituitary hormone deficiencies after traumatic brain injury (TBI). Such deficiencies typically present at time intervals after TBI, especially after mild injuries such as concussions, which makes their diagnosis difficult without careful history taking. It is necessary to improve diagnosis and prevent life threatening or morbid conditions such as those that may occur in deficiencies of adrenocorticotropic hormone (ACTH) or thyroid-stimulating hormone (as known as thyrotropin, TSH), the two most important pituitary hormones in hypopituitarism treatment. Here, we report two cases of isolated ACTH deficiency and one case of isolated TSH deficiency. These patients presented at different time points after concussion and underwent long-term follow-ups.

Keyword

Brain injuries; Adrenocorticotropic hormone; Thyrotropin; Hypopituitarism

MeSH Terms

Adrenocorticotropic Hormone*
Brain Injuries*
Diagnosis
Follow-Up Studies*
Humans
Hypopituitarism
Pituitary Hormones
Thyrotropin*
Adrenocorticotropic Hormone
Pituitary Hormones
Thyrotropin

Figure

• 

  FIGURE 1 T1-weighted sagittal magnetic resonance imaging of case 1 (A), case 2 (B), and case 3 (C) showing a normal pituitary gland.

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