Urogenit Tract Infect.  2017 Apr;12(1):42-48. 10.14777/uti.2017.12.1.42.

Symptoms of Bacillus Calmette-Guerin Cystitis in Bladder Cancer Patients according to Tuberculosis Sequelae by Chest Radiography

• Seo WI
• Kang PM
• Yoon JH
• Choi SJ
• Kim W

• KMID: 2378148
• DOI: http://doi.org/10.14777/uti.2017.12.1.42

Abstract

PURPOSE
Bacillus Calmette-Guerin (BCG) vaccination has been administered to most infants at birth in Korea; however, tuberculosis (TB) remains extant. TB can leave sequelae on chest radiography according to the immune response of the host. We investigated the symptoms of cystitis after intravesica instillations in bladder cancer, depending on the TB sequelae on chest radiography.
MATERIALS AND METHODS
One hundred forty-two patients with non-muscle invasive bladder cancer (NMIBC) underwent transurethral resection and intravesical BCG therapy for bladder cancer. Patients received a BCG induction course"•with or without a maintenance course"•and were divided into the two groups: Group A, which included patients with visible sequelae of TB on chest radiography (n=31) and group B, which included patients without visible sequelae of TB (n=111). Cystitis symptoms of BCG intravesical therapy were compared between the two groups. The recurrence and progression rates of bladder cancer were also analyzed.
RESULTS
The overall rate of cystitis symptoms was 32.3% (10/31) in group A and 33.3% (37/111) in group B. One patient in group A and three in group B did not complete the treatment course due to severe cystitis symptoms (p=0.876). Pyuria was reported when cystitis symptoms occurred in 80% (8/10) in group A and 56.8% (21/37) in group B. The recurrence and progression rates were not different between the two groups.
CONCLUSIONS
Our results show that there was no significant difference of cystitis symptoms in accordance with the presence of TB sequelae in chest radiography when BCG instravesical therapy for NMIBC was performed.

Keyword

Cystitis; BCG vaccine; Tuberculosis; Radiography; Administration, intravesical

MeSH Terms

Administration, Intravesical
Bacillus*
BCG Vaccine
Cystitis*
Humans
Infant
Korea
Mycobacterium bovis
Parturition
Pyuria
Radiography*
Recurrence
Thorax*
Tuberculosis*
Urinary Bladder Neoplasms*
Urinary Bladder*
Vaccination
BCG Vaccine

Figure

• 

  Fig. 1. Results of log-rank test regarding recurrence-free survival in groups A and B. Group A: patients with visible sequelae of TB on chest radiography, group B: patients without visible sequelae of TB on chest radiography.

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