Gut Liver.
2015 Nov;9(6):805-808. 10.5009/gnl14279.
Successful Xenograft of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimen from Human Extrahepatic Cholangiocarcinoma into an Immunodeficient Mouse
- Affiliations
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- 1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. cmcho@knu.ac.kr
- 2Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.
- 3BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University Hospital, Daegu, Korea.
- 4Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease (DMRC), Kyungpook National University Hospital, Daegu, Korea.
- KMID: 2377940
- DOI: http://doi.org/10.5009/gnl14279
Abstract
- Patient-derived tumor xenograft is the transfer of primary human tumors directly into an immunodeficient mouse. Patient-derived tumor xenograft plays an important role in the development and evaluation of new chemotherapeutic agents. We succeeded in generating a patient-derived tumor xenograft of a biliary tumor obtained by endoscopic ultrasound-guided fine-needle aspiration from a patient who had an inoperable extrahepatic cholangiocarcinoma. This patient-derived tumor xenograft will be a promising tool for individualized cancer therapy and can be used in developing new chemotherapeutic agents for the treatment of biliary cancer in the future.
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