Korean J Clin Pharm.  2017 Mar;27(1):30-37. 10.24304/kjcp.2017.27.1.30.

Patient Attitudes and Considerations in Decision toward Participation in Clinical Trials of Chronic Diseases

Affiliations
  • 1Graduate School of Clinical Health Sciences, Ewha Womans University, Seoul 03760, Republic of Korea. sandy.rhie@ewha.ac.kr
  • 2Clinical Trial Center Pharmacy, Seoul National University Hospital, Seoul 03080, Republic of Korea.
  • 3College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. jyoon@pusan.ac.kr
  • 4Division of Life and Pharmaceutical Sciences & College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.

Abstract

BACKGROUND
We investigated the impact of financial compensation on patients' decision of participation in clinical trials and the related factors with patients' attitudes and considerations.
METHODS
A survey questionnaire was placed from October 31 to November 16, 2017 to the subjects who were enrolled in the trials of chronic diseases. Patients' socio-demographic characteristics were collected and the potential reasons for participating in the trials were assessed using 5-likert scores.
RESULTS
Sixty eight of 110 respondents (61.8%) indicated to participate clinical trials regardless of financial compensation. The differences were found between patients who were unwilling to participate without compensation and those who were willing to participate regardless of compensation in mean ages (43.9 years vs. 52.0 years, p<0.05), marital status (married, 47.6% vs 79.4%, p<0.01), religions (yes, 45.2% vs 67.6%, p<0.05) and monthly income (≥3 million won, 19.0% vs 45.6%, p<0.01). The potential reasons for participation in the trials between two groups were doctor's suggestion (52.4% vs. 77.9%, p<0.01), the expectation of health improvement (54.8% vs. 73.5%, p<0.05), the types and numbers of procedure (33.3% vs. 16.2%, p<0.05) and the duration of clinical trials (59.5% vs. 27.9%, p=0.001). In regression analysis, the monthly income of ≥ 3 million won (odd ratio, OR=3.221, p=0.026,) and the duration of trials (OR=0.290, p=0.017) were related to the group with the willingness to participate regardless of compensation.
CONCLUSION
This stady showed that more than half of study subjects would participate in the clinical trials of chronic diseases regardless of financial compensation.

Keyword

Clinical trials; chronic disease; financial compensation

MeSH Terms

Chronic Disease*
Compensation and Redress
Humans
Marital Status
Surveys and Questionnaires
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