Ann Coloproctol.  2017 Feb;33(1):39-42. 10.3393/ac.2017.33.1.39.

High-Grade Mixed Adenoneuroendocrine Carcinoma in the Cecum: A Case Report

• Shin SH
• Kim SH
• Jung SH
• Jang JW
• Kang MS
• Kim SI
• Kim JH
• Lee JH

• KMID: 2377389
• DOI: http://doi.org/10.3393/ac.2017.33.1.39

Abstract

Gastrointestinal neoplasms with an exocrine and a neuroendocrine component are rare. Such neoplasms are called "mixed adenoneuroendocrine carcinomas" (MANECs) according to the most recent World Health Organization classification of gastrointestinal tract neoplasms. MANECs have no specific findings that distinguish them from pure adenocarcinomas. In addition, the optimal management strategy of MANECs is largely unknown. We describe the case of a 32-year-old man with dizziness and abdominal bloating. A cecal mass was suspected based on an image study done at a local clinic. We evaluated the cecal mass by using colonoscopy, contrast enhanced computed tomography of the abdomen, positron emission tomography-computed tomography, and laboratory studies. The patient underwent a right hemicolectomy and adjuvant chemotherapy. The final histopathological diagnosis was a high-grade MANEC of the ascending colon, tumor stage T3N2M0.

Keyword

Mixed adenoneuroendocrine carcinomas; MANECs

MeSH Terms

Abdomen
Adenocarcinoma
Adult
Cecum*
Chemotherapy, Adjuvant
Classification
Colon, Ascending
Colonoscopy
Diagnosis
Dizziness
Electrons
Gastrointestinal Neoplasms
Gastrointestinal Tract
Humans
World Health Organization