Yeungnam Univ J Med.  1990 Jun;7(1):151-163. 10.12701/yujm.1990.7.1.151.

A Clinical and Serologic Study of 21 Cases of Tsutsugamushi Disease Confirmed by Serologic test

• Park JS
• Kweon YS
• Lee KH
• Hyun MS
• Chung MK
• Lee HW

• KMID: 2377317
• DOI: http://doi.org/10.12701/yujm.1990.7.1.151

Abstract

Tsutsugamushi disease is an acute febrile disease caused by Rickettsia tsutsugamushi, and which has been reported with increasing frequency thorough the nation since 1986. We experienced 21 cases of Tsutsugamushi Disease diagnosed with serologic test occurring in Taegu city and Kyungpook province during October-November, 1989. The results of survey are as follow. 1) Of 21 cases, 12 (57%) were males and 9 (43%) were females, and the peak incidence was the 4th decade. 2) The outbreak was in October to November and the peak incidence was in October. 3) The most frequent symptoms were fever and chill (100%), myalgia (95%), headache (90%), Eschar and rash were observed in 18 patients (86%) and the eschar was detected in all over the body, especially thorax (33%) and lower extremity (22%). 4) Laboratory features were SGOT elevation (83%), SGPT elevation (61%), LDH elevation (67%), leukocytosis (38%). 5) Indirect immunofluorescent antibody test was done in 18 patients and the antibody titer was above 1:320 in all patients. 6) The chloramphenicol, tetracycline or doxycycline regimens were very effective and mean duration of defervescence from initiation of therapy was 1.3 days. 7) The complication such as meningitis or shock, was not seen.

Keyword

Tsutsugamushi disease; indirect immunofluorescent antibody test

MeSH Terms

Alanine Transaminase
Aspartate Aminotransferases
Chloramphenicol
Daegu
Doxycycline
Exanthema
Female
Fever
Gyeongsangbuk-do
Headache
Humans
Incidence
Leukocytosis
Lower Extremity
Male
Meningitis
Myalgia
Orientia tsutsugamushi
Scrub Typhus*
Serologic Tests*
Shock
Tetracycline
Thorax
Alanine Transaminase
Aspartate Aminotransferases
Chloramphenicol
Doxycycline
Tetracycline