Yeungnam Univ J Med.  1989 Jun;6(1):171-178. 10.12701/yujm.1989.6.1.171.

Eaton-Lambert Syndrome with Small Cell Lung Cancer: A case report

• Lee KH
• Chung MK
• Hyun MS
• Chung JC
• Lee HW
• Hah JS
• Byun YJ

• KMID: 2377273
• DOI: http://doi.org/10.12701/yujm.1989.6.1.171

Abstract

Eaton Lambert Syndrome (ELS) is a disorder of neuromuscular transmission. The defect of neuromuscular transmission is due to decrease in the release of acetylcholine quanta from nerve terminal. This syndrome is frequently associated with bronchogenic carcinoma. The diagnosis is established by electromyography, which characteristically shows 1) low amplitude of evoked compound muscle potential to a single supramaximal stimulus on nerve, 2) significant decremental response at low rates of stimulation 3) marked incremental response at high rates of stimulation. Our patient is 52year old man with dyspnea, coughing and muscle weakness of proximal lower limbs. He has small cell lung cancer and associated with ELS, Superior vena cava syndrome and has metastatic lesion on right supraclavicular lymph node confirmed by pathology. Metastatic mass and SVC syndrome are marked improved following chemotherapy and radiotherapy, however follow up EMG finding does not improved. We are here reporting one case which considered compatible for ELS, with a few elementary reviewed literatures.

MeSH Terms

Acetylcholine
Carcinoma, Bronchogenic
Cough
Diagnosis
Drug Therapy
Dyspnea
Electromyography
Follow-Up Studies
Humans
Lambert-Eaton Myasthenic Syndrome*
Lower Extremity
Lymph Nodes
Muscle Weakness
Pathology
Radiotherapy
Small Cell Lung Carcinoma*
Superior Vena Cava Syndrome
Acetylcholine