J Clin Neurol.  2012 Dec;8(4):305-307. 10.3988/jcn.2012.8.4.305.

A Case of Lambert-Eaton Myasthenic Syndrome with Small-Cell Lung Cancer and Transient Increase in Anti-Acetylcholine-Receptor-Binding Antibody Titer

Affiliations
  • 1Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. sunwooin@yumc.yonsei.ac.kr
  • 2Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.

Abstract

BACKGROUND
Lambert-Eaton myasthenic syndrome (LEMS) is a presynaptic neuromuscular junction disorder that is most frequently associated with small-cell lung cancer (SCLC). The titers of antibodies against voltage-gated calcium channels are frequently increased in LEMS, but only rarely is titer of anti-acetylcholine-receptor-binding antibodies (AChR-abs) increased. CASE REPORT: A 57-year-old male was admitted to our hospital due to dry mouth and eyes and progressive proximal limb weakness of 2 months duration. The results of a repetitive nerve stimulation test disclosed all criteria for the electrophysiological LEMS pattern, and the patient's AChR-abs titer was 0.587 nmol/L. At a follow-up performed 5 years after successful treatment of SCLC and LEMS, his AChR-abs titer had decreased to 0.001 nmol/L.
CONCLUSIONS
We suggest that this was a case of transient pseudopositivity of AChR-abs in SCLC with LEMS.

Keyword

Lambert-Eaton myasthenic syndrome; small-cell lung carcinoma; myasthenia gravis
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