J Korean Assoc Oral Maxillofac Surg.  2017 Apr;43(2):63-69. 10.5125/jkaoms.2017.43.2.63.

The role of nuclear factor I-C in tooth and bone development

• Roh SY
• Park JC

• KMID: 2377007
• DOI: http://doi.org/10.5125/jkaoms.2017.43.2.63

Abstract

Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic(-/-) mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Krüppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.

Keyword

Nuclear factor I-C; Dentinogenesis; Osteogenesis; Osteoporosis

MeSH Terms

Animals
Bone Development*
Dentinogenesis
Mesenchymal Stromal Cells
Mice
NFI Transcription Factors*
Odontoblasts
Osteoblasts
Osteogenesis
Osteoporosis
Tooth*
NFI Transcription Factors

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